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Thursday
| Time | Matchup | Channel |
| 12:15 | 4 Duke vs. 13 UNC Wilmington | CBS |
| 12:40 | 8 Texas Tech vs. 9 Butler | truTV |
| 1:30 | 8 Colorado vs. 9 UConn | TNT |
| 2:00 | 4 Iowa State vs. 13 Iona | TBS |
| 2:45 | 5 Baylor vs. 12 Yale | CBS |
| 3:10 | 1 Virginia vs. 16 Hampton | truTV |
| 4:00 | 1 Kansas vs. 16 Austin Peay | TNT |
| 4:30 | 5 Purdue vs. 12 Arkansas-Little Rock | TBS |
| 6:50 | 3 Miami vs. 14 Buffalo | TNT |
| 7:10 | 5 Indiana vs. 12 Chattanooga | CBS |
| 7:20 | 1 North Carolina vs. Florida Gulf Coast | TBS |
| 7:27 | 3 Utah vs. 14 Fresno State | truTV |
| 9:20 | 6 Arizona vs. 11 Wichita State | TNT |
| 9:40 | 4 Kentucky vs. 13 Stony Brook | CBS |
| 9:50 | 8 USC vs. 9 Providence | TBS |
| 9:57 | 6 Seton Hall vs. 11 Gonzaga | truTV |
Friday
| Time | Matchup | Channel |
| 12:15 | 7 Dayton vs. 10 Syracuse | CBS |
| 12:40 | 2 Villanova vs. 15 UNC Asheville | truTV |
| 1:30 | 7 Oregon State vs. 10 VCU | TNT |
| 2:00 | 4 California vs. 13 Hawaii | TBS |
| 2:45 | 2 Michigan State vs. 15 Middle Tennessee State | CBS |
| 3:10 | 7 Iowa vs. 10 Temple | truTV |
| 4:00 | 2 Oklahoma vs. 15 CSU Bakersfield | TNT |
| 4:30 | 5 Maryland vs. 12 South Dakota State | TBS |
| 6:50 | 7 Wisconsin vs. 10 Pittsburgh | TNT |
| 7:10 | 3 West Virginia vs. 14 Stephen F. Austin | CBS |
| 7:20 | 3 Texas A&M vs. 14 Green Bay | TBS |
| 7:27 | 1 Oregon vs. 16 Holy Cross | truTV |
| 9:20 | 2 Xavier vs. 15 Weber State | TNT |
| 9:40 | 6 Notre Dame vs. 11 Michigan | CBS |
| 9:50 | 6 Texas vs. 11 Northern Iowa | TBS |
| 9:57 | 8 St. Joseph's vs. 9 Cincinnati | truTV |
Don't forget that if you're at work, you can watch all of these games on March Madness Live, formerly known as March Madness on Demand.