IU begins November with a home game against a tough program that has nonetheless played down to IU's level over the years. IU beat Iowa in 2006 and 2007 and played very competitively against the Hawkeyes in 2009 and 2010. Last year was rough, of course, but by default (IU's other conference home games are against MSU, OSU, and Wisconsin), the game against the Hawkeyes may be IU's most winnable Big Ten home game.

In the 2011 game, IU managed to hang with Iowa until the middle of the second quarter, when Iowa went on a run to turn a 14-14 tie into a 35-14 halftime lead. Quarterback James Vandenberg, now a senior, played well against IU and will be the leader of the 2012 Hawkeyes. Last season, Vandenberg threw for 3022 yards. His completion percentage (58.7) wasn't terribly impressive, but he threw for 25 TDs to only 7 interceptions. At running back, however, Iowa is depleted. 2011 leading rusher Marcus Coker transferred, De'Andre Johnson was dismissed a couple of weeks ago because of multiple problems with the law, and Jordan Canzieri tore his ACl. That leaves Damon Bullock, with 10 carries for 20 yards, as the only returning experience. This article mentions incoming freshmen Greg Garmon and Barkley Hill as possible replacements. At receiver, the Hawkeyes must replace the excellent Marvin McNutt, but Keenan Davis, who gained 713 yards and caught four TDS, returns, as do Kevonte Martin-Manley, and tight end CJ Fiedorwicz. On the line, which often is a strength for the Hawkeyes, Iowa returns two full-time starters from last season, including coach's son James Ferentz.