Technically, this is IU's first game against the Big 12 Conference. Although the Big 12 is the obvious successor to the Big 8, technically (and much to the chagrin of the Big 8 holdovers) the Big 12 is a new conference that began play in 1996. IU's last game against a current Big 12 member was in 1992, a 20-10 win over Missouri in Bloomington. That was the last game of an eight year series against the Tigers, and the Hoosiers were 6-0-2 against Mizzou during that stretch. IU's last loss to a current Big 12 member was a loss to Colorado in 1979. IU has a modest 2 game winning streak against the Big 12 members (the 1992 Missouri game and the 1991 Copper Bowl against Baylor) and a ten game unbeaten streak.

IU has a respectable 25-17-6 record against current Big 12 members. IU has never played Iowa State, Texas A&M, or Texas Tech.

Believe it or not, IU's 9 wins against Nebraska are the most wins IU has against any major non-conference opponent other than Kentucky.

IU's only previous game against Oklahoma State was in 1930, a 7-7 tie in Bloomington against what then was known as Oklahoma A&M.

Oklahoma State is 1-8-1 against Big Ten opponents. The Cowboys have never played Illinois, Michigan State, Northwestern, Penn State, or Wisconsin. The only OSU win over a Big Ten school was a 6-0 win over Iowa in 1930, the same year that the Hoosiers and the Cowboys tied.

Two of OSU's 17 bowl appearances have been against Big Ten schools: the Cowboys lost 33-20 to Purdue in the 1997 Alamo Bowl and 33-7 to Ohio State in the 2004 Alamo Bowl.

The 1991 Copper Bowl against Baylor (then of the Southwest Conference) is IU's only postseason appearance against a current Big 12 team.